Senior/Lead Scientist – Cell & Molecular Biology

Job title: Senior/Lead Scientist – Cell & Molecular Biology

Company: Lonza

Job description: Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

We are currently looking for a Senior Scientist with experience in Molecular/Synthetic Biology and Mammalian Cell Culture to complement our Vectorology R&D team in Cambridge. In this role, you will be working on projects that create CHO cell lines and gene expression platforms with enhanced performance characteristics.

You will be working within a team of scientists with a diverse range of skills and experience across a range of fields including cell and molecular biology, mammalian cell culture, recombinant protein expression, protein engineering, and cell engineering. In this role you will have the opportunity to join an innovative high-performance team that will develop new and emerging technologies in the field of biologics manufacturing.

Key Responsibilities:

  • Generation of novel vector platforms incorporating panels of synthetic genetic elements for enhancing cellular production capabilities
  • Testing of next generation vector systems in a transient and stable context including high level expression of complex biological molecules in fed-batch cultures
  • Collate, analyse, evaluate and sign-off data to produce high quality information and records
  • Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression
  • 80% lab based role

Key requirements and skills:

  • PhD in Life Sciences/ Molecular Biology/ Biotechnology, together with practical experience in an industrial setting
  • R&D technological background in molecular biology, and relevant mammalian cell culture techniques
  • Key cell culture techniques desired include CHO cell culture, transient expression, and stable pool generation, fed-batch culture
  • Key molecular biology skills desired include gene cloning and vector construction including Golden Gate/ Gibson assembly and experience in the use of suitable software packages such as SnapGene or Lasergene
  • Extensive molecular biology experience in methods such as; gene cloning, expression vector design and manipulation, DNA extraction and purification, PCR/qPCR, gel electrophoresis, SDS-PAGE and Western blotting
  • Experience with DNA regulatory elements (e.g. promoters, insulators) is highly advantageous
  • Experience with different nucleofection systems, automation and liquid handling equipment and evaluation of cell lines by flow cytometry is advantageous
  • Evidence of innovation and solution-finding in a scientific setting

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.


Expected salary:

Location: Cambridge

Job date: Thu, 30 Nov 2023 07:35:28 GMT

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