Principal Scientist – Protein Machine Learning

  • Full Time
  • Canada

Job title: Principal Scientist – Protein Machine Learning

Company: Roche

Job description: The Position

Principal Scientist – Protein Machine Learning

Job Description

We seek a highly motivated Principal Scientist to join the Reagent Bioinformatics team in Roche Diagnostics Solutions to develop and apply machine learning and other computational techniques to protein engineering. The successful candidate will collaborate with biologists, chemists, computational scientists, bioinformatics scientists, and engineers to create and continuously improve enzymes critical to our portfolio of reagents, assays, and instruments.


Proactively engage cross-functional teams to generate datasets, share/build scientific knowledge, and appropriately apply AI/ML methods to achieve enzyme engineering goals

Develop methods to predict mutant performance that will guide protein design and in silico library selection

Research and evaluate protein language models and other deep learning methods (e.g., diffusion, neural networks)

Train and optimize AI/ML models (e.g., hyper-parameter tuning, regularization techniques)

Assess sequence-based, structure-based, and combinations of methods as well as data encoding approaches for amino acids as well as experimental conditions

Independently recommend next steps for data analysis, method development, and experiments

Regularly present and communicate project updates to different teams in the organization

Collaborate closely with protein biochemistry, molecular biology, engineering, and other computational teams on experimental design, data collection, QC, algorithm design, data analysis, visualization, and communication of results

Required Skills & Experience:

Ph.D. or equivalent experience in machine learning or related quantitative field (Computer Science, Statistics, Applied Mathematics, Computational Biology)

Demonstrated experience applying AI/ML methods to solve protein engineering problems

In-depth knowledge of AI/ML methods suitable for protein sequence and structure questions

Excellent programming skills, especially python and common ML libraries such as scikit-learn, PyTorch, TensorFlow, and proficient in working in a Linux environment on a shared compute cluster and/or cloud environment with CPUs and GPUs

Strong analytical skills to identify key questions quickly and develop innovative solutions

Proven ability to proactively evaluate methods and propose improvements

Ability to thrive in collaborative multi-disciplinary teams and adapt to changing business and technical environments

Strong written and verbal communication skills with ability to adjust to audiences of varying technical backgrounds

This position is not eligible for relocation support.

NOTE: All employment is conditional upon the completing and obtaining a satisfactory background check, including educational, employment, references and criminal records (for which a pardon has not been granted) checks.

AGENCY NOTICE: Please note that Roche Canada does not accept unsolicited resumes from recruiters or employment agencies. In the absence of a signed Services Agreement with agency/recruiter, Roche Canada will not consider or agree to payment of any referral compensation or recruiter fee. In the event a recruiter or agency submits a resume or candidate without a previously signed agreement, Roche Canada explicitly reserves the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche Pharma Canada has its office in Mississauga, Ontario and employs over 850 employees. The Mississauga facility is bright, vibrant, fosters collaboration and teamwork, and is reflective of Roche’s truly innovative culture.

As of January 4, 2022, Roche requires all new employees who work in Canada to be fully vaccinated against COVID-19 on the date they take office. This requirement is a condition of employment at Roche that applies regardless of whether the position is on a Roche campus or remotely. If you have a valid reason for not being fully immunized, which is limited to certain specific medical reasons or other valid reasons protected by applicable human rights laws, you may request an exemption and / or adaptation measures regarding this vaccination requirement.

Roche is an Equal Opportunity Employer.

Expected salary:

Location: Canada

Job date: Sun, 10 Dec 2023 23:37:59 GMT

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